100 years of suramin
N Wiedemar, DA Hauser, P Mäser - Antimicrobial agents and …, 2020 - Am Soc Microbiol
… Here, we provide an overview of the many different … , more specific, and less toxic molecules
can be identified for the … least) two pathways for receptor-mediated endocytosis of suramin in …
can be identified for the … least) two pathways for receptor-mediated endocytosis of suramin in …
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
… In the last two decades, appreciable progress has been … , chemotherapeutic agents have
significant toxicity and badly … In a cohort study with 15,052 colorectal cancer patients, that …
significant toxicity and badly … In a cohort study with 15,052 colorectal cancer patients, that …
[HTML][HTML] Pentosan Polysulfate affords pleotropic protection to multiple cells and tissues
… to unmodified suramin and these are also less toxic [110]. … in vitro, and it has been proposed
as a novel therapeutic agent to … PPS or isotonic saline was injected twice weekly for 6 weeks …
as a novel therapeutic agent to … PPS or isotonic saline was injected twice weekly for 6 weeks …
Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment
… resistance in MM patients, neuro-toxicities, and little efficacy in … therapeutic agent for multiple
myeloma (MM) and mantle cell … , BTZ has shown significant anticancer activity in plasma cell …
myeloma (MM) and mantle cell … , BTZ has shown significant anticancer activity in plasma cell …
[HTML][HTML] Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
R Listro, G Rossino, F Piaggi, FF Sonekan… - Frontiers in …, 2022 - frontiersin.org
… truncated suramin derivatives were ineffective against the tumor cell … )thiazol-2-yl urea
derivatives as therapeutic agents) this year, … activity against human colon cancer cells, underwent …
derivatives as therapeutic agents) this year, … activity against human colon cancer cells, underwent …
Old polyanionic drug suramin suppresses detrimental cytotoxicity of the host defense peptide LL-37
M Quemé-Peña, M Ricci, T Juhász… - ACS Pharmacology & …, 2020 - ACS Publications
… to provide a viable solution. Here, we demonstrate that the reduction of LL-37 toxicity might
be … Moreover, a comparison with other therapeutic agents having common features unveiled …
be … Moreover, a comparison with other therapeutic agents having common features unveiled …
[HTML][HTML] Coumarins and coumarin-related compounds in pharmacotherapy of cancer
… due to their low toxicity, low drug resistance, low cost and … used as preventive and therapeutic
agents in cancer therapy. These … In this study, it has been shown that esculetin provides a …
agents in cancer therapy. These … In this study, it has been shown that esculetin provides a …
[HTML][HTML] Synthesis of Novel Suramin Analogs With Anti-Proliferative Activity via FGF1 and FGFRD2 Blockade
… show potential as novel therapeutic agents for their anti-… of suramin was understood, less
toxic and more specific new … , suramin has been tested for NSCLC’s, prostate cancer, and …
toxic and more specific new … , suramin has been tested for NSCLC’s, prostate cancer, and …
Anti-breast cancer potential of a new xanthine derivative: in silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies
… are needed to explore its potential as a therapeutic agent. … In colorectal cancer, theobromine
was able to induce … , and its potential toxicity, ADMET prediction offers valuable insights into …
was able to induce … , and its potential toxicity, ADMET prediction offers valuable insights into …
[HTML][HTML] Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
… The C-terminal region has two highly conserved motifs: a nucleotidyltransferase (NTase) …
/translocation was rarely observed in some human colon cancer cell lines. This study indicated …
/translocation was rarely observed in some human colon cancer cell lines. This study indicated …